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Test Bank for Hematology in Practice 3rd by Ciesla

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  • ISBN-10 ‏ : ‎ 0803668244
  • ISBN-13 ‏ : ‎ 978-0803668249
  • Author:   Betty Ciesla

I highly recommend this book.“… straight forward and I would recommend this book to anyone looking for a solid understanding of the most important concepts behind the tests performed in a modern hematology laboratory. Some textbooks today make it difficult for hematology students and lab professionals alike to figure out what it is that they “really need to know” to be effective and competent in the lab. Hematology in Practice addresses exactly this problem. In addition, this book will give a student an understanding that is more than good enough to pass general and categorical licensing exams.”—Michael B., Amazon Reviewer

Basic principles of hematology made memorable. Build a solid understanding of hematology in the context of practical laboratory practice and principles. Visual language, innovative  case studies, role-playing troubleshooting cases, and laboratory protocols bring laboratory practice to life.

Superbly organized, this reader-friendly text breaks a complex subject into easy-to-follow, manageable sections. Begin with the basic principles of hematology; discover red and white blood cell disorders; journey through hemostasis and disorders of coagulation; and then explore the procedures needed in the laboratory.

 

Table of Content:

  1. Part I: Basic Hematology Principles
  2. Chapter 1: Introduction to Hematology and Basic Laboratory Practice
  3. Introduction to Hematology
  4. The Microscope
  5. Significant Parts of the Microscope
  6. Care of the Microscope
  7. Corrective Actions in Light Microscopy
  8. Innovations in Microscopy
  9. Standard Precautions
  10. Personal Protective Equipment
  11. Safety Practices Other Than Personal Protective Equipment
  12. Chemical and Environmental Hazards
  13. Basic Concepts of Quality Assurance Plans in the Hematology Laboratory
  14. Quality Control Monitoring in the Hematology Laboratory
  15. Reference Intervals
  16. Delta Checks
  17. Reflex Testing
  18. Critical Values
  19. Preanalytic Variables
  20. Postanalytic Variables
  21. Chapter 2: From Hematopoiesis to the Complete Blood Count
  22. Hematopoiesis: The Origin of Cell Development
  23. The Spleen as an Indicator Organ of Hematopoietic Health
  24. Functions of the Spleen
  25. Potential Risks of Splenectomy
  26. Bone Marrow and Myeloid:Erythroid Ratio
  27. Alterations in Myeloid:Erythroid Ratio
  28. Role of Stem Cells and Cytokines
  29. Erythropoietin
  30. Bone Marrow Analysis
  31. Bone Marrow Procedure
  32. Bone Marrow Report
  33. Complete Blood Count
  34. Morphologic Classification of Anemias
  35. Calculating Red Blood Cell Indices and Their Role in Indicating Sample Integrity
  36. Value of Red Blood Cell Distribution Width
  37. Critical Values
  38. Clinical Approach to Anemias
  39. Chapter 3: Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology
  40. Basic Red Blood Cell Production
  41. Red Blood Cell Maturation
  42. Features of Red Blood Cell Development
  43. Red Blood Cell Membrane Development and Function
  44. Composition of Lipids in the Interior and Exterior Layers
  45. Composition of Proteins in the Lipid Bilayers: Integral Proteins
  46. Cytoskeleton: Peripheral Proteins
  47. Red Blood Cell Metabolism
  48. Abnormal Red Blood Cell Morphology
  49. Variations in Red Blood Cell Size
  50. Variations in Red Blood Cell Color
  51. Variations in Red Blood Cell Shape
  52. Red Blood Cell Inclusions
  53. Value of the Reticulocyte Count
  54. Chapter 4: Hemoglobin Function and Principles of Hemolysis
  55. Hemoglobin Structure and Synthesis
  56. Genetics and Chain Formation of Hemoglobin
  57. Hemoglobin Function
  58. Oxygen Dissociation Curve
  59. Abnormal Hemoglobins
  60. Hemolysis
  61. Types and Physiology of Hemolysis
  62. Laboratory Evidence of Hemolysis
  63. Classifications Relevant to the Hemolytic Anemias
  64. Part II: Red Blood Cell Disorders
  65. Chapter 5: The Microcytic Anemias
  66. Introduction
  67. Iron Intake and Iron Absorption
  68. Iron Storage and Recycled Iron
  69. Iron Deficiency Anemia
  70. Pathophysiology and Symptoms
  71. Tests Used to Help Diagnose Iron Deficiency
  72. Treatment for Iron Deficiency
  73. Anemia of Chronic Disease and Inflammation: Pathophysiology, Diagnosis, and Treatment
  74. Sideroblastic Anemias
  75. Hereditary Hemochromatosis (Congenital Iron Overload)
  76. Thalassemia Syndromes
  77. Pathophysiology of Thalassemias
  78. Alpha Thalassemia
  79. Beta Thalassemia Major: Cooley’s Anemia, Mediterranean Anemia
  80. Thalassemia Intermedia and Beta Thalassemia Trait
  81. Chapter 6: The Macrocytic Anemias
  82. Macrocytic Anemias and the Megaloblastic Process
  83. Red Blood Cell Precursors in Megaloblastic Anemia
  84. Ineffective Erythropoiesis in Megaloblastic Anemia
  85. Pernicious Anemia as a Subset of Megaloblastic Anemias
  86. Vitamin B12 and Folic Acid: Nutritional Requirements and Metabolism
  87. Vitamin B12 and Folic Acid Deficiency
  88. Vitamin B12 Transport Into the Bone Marrow
  89. Clinical Features of Patients With Megaloblastic Anemia
  90. Hematologic Features of Megaloblastic Anemias
  91. Laboratory Diagnosis of Megaloblastic Anemias
  92. Serum Vitamin B12 Levels and Folic Acid Levels
  93. Serum Methylmalonic Acid and Homocysteine
  94. Intrinsic Factor and Parietal Cell Antibodies
  95. Treatment and Response of Patients With Megaloblastic Anemia
  96. Macrocytic Anemias That Are Not Megaloblastic
  97. Chapter 7: Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders
  98. Role of the Spleen in Red Blood Cell Membrane Disorders
  99. Hereditary Spherocytosis
  100. Genetics and Pathophysiology of Hereditary Spherocytosis
  101. Clinical Presentation in Hereditary Spherocytosis
  102. Laboratory Diagnosis of Hereditary Spherocytosis
  103. Treatment and Management of Hereditary Spherocytosis
  104. Hereditary Elliptocytosis
  105. Common Hereditary Elliptocytosis
  106. Southeast Asian Ovalocytosis
  107. Spherocytic Hereditary Elliptocytosis
  108. Hereditary Pyropoikilocytosis
  109. Hereditary Stomatocytosis and Hereditary Xerocytosis
  110. Glucose-6-Phosphate Dehydrogenase Deficiency
  111. Genetics of Glucose-6-Phosphate Dehydrogenase Deficiency
  112. Clinical Manifestations of Glucose-6-Phosphate Dehydrogenase Deficiency
  113. Acute Hemolytic Anemia
  114. Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency
  115. Pyruvate Kinase Deficiency
  116. Miscellaneous Red Blood Cell Disorders
  117. Aplastic Anemia
  118. Fanconi’s Anemia
  119. Diamond-Blackfan Anemia
  120. Paroxysmal Nocturnal Hemoglobinuria
  121. Cold Agglutinin Syndrome
  122. Paroxysmal Cold Hemoglobinuria
  123. Congenital Dyserythropoietic Anemias
  124. Acquired Anemias of Variable External Causes
  125. Chapter 8: The Normochromic Anemias Caused by Hemoglobinopathies
  126. General Description of Hemoglobinopathies
  127. Sickle Cell Anemia
  128. Genetics and Incidence of Sickle Cell Anemia
  129. Pathophysiology of Sickling Process
  130. Clinical Considerations for Sickle Cell Anemia
  131. Laboratory Diagnosis
  132. Sickle Cell Trait
  133. Hemoglobin C Disease and Trait and Hemoglobin SC
  134. Variant Hemoglobins
  135. Hemoglobin S–Beta Thalassemia
  136. Hemoglobin E
  137. Hemoglobin DPunjab and Hemoglobin GPhila
  138. Hemoglobin OArab
  139. Part III: White Blood Cell Disorders
  140. Chapter 9: Leukopoiesis, WBC Differential, and Lymphocyte Function
  141. Leukopoiesis
  142. Stages of Leukocyte Maturation
  143. Features of Cell Identification
  144. Lymphocyte Origin and Function
  145. Lymphocyte Populations
  146. Travel Path of Lymphocytes
  147. Lymphocytes and Development of Immunocompetence
  148. Response of Lymphocytes to Antigenic Stimulation
  149. Lymphocyte Cell Markers and Cluster of Differentiation
  150. Leukocyte Count From Complete Blood Cell Count to Differential
  151. Manual Differential Versus Differential Scan
  152. Relative Versus Absolute Values
  153. Chapter 10: Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases
  154. Introduction to White Blood Cell Disorders
  155. Quantitative Changes in White Blood Cells
  156. Specific Terminology Relating to Quantitative White Blood Cell Changes
  157. Stages of White Blood Cell Phagocytosis
  158. Qualitative Defects of White Blood Cells
  159. Toxic Changes in White Blood Cells
  160. Human Ehrlichiosis
  161. Nuclear Abnormalities: Hypersegmentation
  162. Hereditary White Blood Cell Disorders
  163. May-Hegglin Anomaly
  164. Alder’s Anomaly
  165. Pelger-Huët Anomaly
  166. Chédiak-Higashi Syndrome
  167. Reactive Lymphocytosis in Common Disease States
  168. Other Viral Sources of Reactive Lymphocytosis
  169. Effect of HIV/AIDS on Hematology Parameters
  170. Lipid Storage Diseases
  171. Common Features of a Few Lipid Storage Diseases
  172. Bone Marrow Cells in Lipid Storage Disorders
  173. Bacteria and Other Unexpected White Blood Cell Changes
  174. Chapter 11: Acute Leukemias
  175. Definition of Leukemia
  176. Comparing Acute and Chronic Leukemia
  177. Leukemia History
  178. Acute Myeloid Leukemia
  179. Epidemiology
  180. Clinical Features
  181. Laboratory Features
  182. Classification
  183. Acute Leukemias of Ambiguous Lineage
  184. Important Acute Myeloid Leukemia Prognostic Factors
  185. Acute Lymphoblastic Leukemia
  186. Epidemiology
  187. Clinical Features
  188. Classifications
  189. Prognosis in Acute Lymphoblastic Leukemia
  190. Chapter 12: Myeloproliferative Neoplasms
  191. Introduction to Myeloproliferative Neoplasms
  192. World Health Organization Classifications
  193. Chronic Myeloid Leukemia BCR-ABL1+
  194. Pathophysiology
  195. Clinical Features and Symptoms
  196. Peripheral Blood and Bone Marrow
  197. Diagnosis
  198. Treatment
  199. Prognosis
  200. Chronic Neutrophilic Leukemia
  201. Chronic Eosinophilic Leukemia Not Otherwise Specified
  202. Polycythemia Vera
  203. Pathophysiology
  204. Clinical Features and Symptoms
  205. Peripheral Blood and Bone Marrow Findings
  206. Diagnosis
  207. Treatment
  208. Prognosis
  209. Primary Myelofibrosis
  210. Pathophysiology
  211. Clinical Features and Symptoms
  212. Peripheral Blood and Bone Marrow Findings
  213. Diagnosis
  214. Treatment
  215. Prognosis
  216. Essential Thrombocythemia
  217. Pathophysiology
  218. Clinical Features and Symptoms
  219. Peripheral Blood and Bone Marrow Findings
  220. Diagnosis
  221. Treatment
  222. Prognosis
  223. Mastocytosis
  224. Chapter 13: Lymphoproliferative Disorders and Related Plasma Cell Disorders
  225. Lymphoid Malignancies
  226. Chronic Lymphocytic Leukemia
  227. Prolymphocytic Leukemia
  228. Hairy Cell Leukemia
  229. Hodgkin’s Lymphoma and Non-Hodgkin’s Lymphoma
  230. Sézary Syndrome
  231. Plasma Cell Disorders
  232. Plasma Cell Structure and Function
  233. Multiple Myeloma
  234. Waldenström’s Macroglobulinemia
  235. Chapter 14: The Myelodysplastic Syndromes
  236. Introduction to Myelodysplastic Syndromes
  237. Pathophysiology
  238. Chromosomal Abnormalities
  239. Common Features and Clinical Symptoms
  240. How to Recognize Dysplasia
  241. Classification of Myelodysplastic Syndromes
  242. Specific Features of 2016 World Health Organization Classification
  243. Prognostic Factors and Clinical Management
  244. Part IV: Hemostasis and Disorders of Coagulation
  245. Chapter 15: Overview of Hemostasis and Platelet Physiology
  246. Normal Hemostasis: Overview
  247. Vascular System
  248. Vasoconstriction
  249. Contribution of Endothelial Cells
  250. Evaluation of Endothelial Cells
  251. Platelets and Primary Hemostasis
  252. Platelet Structure and Physiology
  253. Platelet Function in Primary Hemostasis
  254. Platelet Properties
  255. Evaluation of Platelets
  256. Hemostatic Proteins and Secondary Hemostasis
  257. Coagulation Factors (Coagulation Cascade)
  258. Regulatory Inhibitors
  259. Hemostatic Protein Groups
  260. Fibrinolytic System
  261. Screening Tests for Evaluation of Bleeding Disorders
  262. Chapter 16: Quantitative and Qualitative Platelet Disorders
  263. Quantitative Disorders of Platelets
  264. Thrombocytopenia Related to Sample Integrity and Preanalytic Variables
  265. Thrombocytopenia Related to Decreased Production
  266. Thrombocytopenia Related to Altered Distribution of Platelets
  267. Thrombocytopenia Related to Immune Effect of Specific Drugs or Antibody Formation
  268. Thrombocytopenia Related to Consumption of Platelets
  269. Thrombocytosis
  270. Inherited Qualitative Disorders of Platelets
  271. Disorders of Adhesion
  272. Platelet Release Defects
  273. Acquired Defects of Platelet Function
  274. Vascular Disorders Leading to Platelet Dysfunction
  275. Chapter 17: Defects of Plasma Clotting Factors
  276. Plasma Clotting Factors and Hemophilias
  277. Evaluation of a Bleeding Disorder
  278. Treatment of Hemophilia A Patients
  279. Quality-of-Life Issues for Hemophilia A Patients
  280. Factor VIII Inhibitors
  281. Hemophilia B (Christmas Disease)
  282. Congenital Factor Deficiencies
  283. Congenital Factor Deficiencies With Bleeding Manifestations
  284. Congenital Factor Deficiencies in Which Bleeding Is Mild or Absent
  285. Factor XIII Deficiency
  286. Bleeding Secondary to a Chronic Disease Process
  287. Role of Vitamin K in Hemostasis
  288. Vitamin K Deficiency and Subsequent Treatment
  289. Chapter 18: Fibrinogen, Thrombin, and the Fibrinolytic System
  290. Overview of Fibrinogen in Clot Formation and Lysis
  291. Disorders of Fibrinogen
  292. Afibrinogenemia
  293. Hypofibrinogenemia
  294. Dysfibrinogenemia
  295. Multiple Roles of Thrombin in Hemostasis
  296. Fibrinolysis
  297. Clot Dissolution
  298. Naturally Occurring Inhibitors of Fibrinolysis
  299. Measurable Products of the Fibrinolytic System
  300. Disseminated Intravascular Coagulation
  301. Mechanism of Acute Disseminated Intravascular Coagulation
  302. Primary Fibrinolysis
  303. Clinical Symptoms and Laboratory Results in Acute Disseminated Intravascular Coagulation
  304. Treatment of Acute Disseminated Intravascular Coagulation
  305. Chapter 19: Introduction to Thrombosis and Anticoagulant Therapy
  306. Thrombophilia and Thrombosis—an Overview
  307. Physiologic and Pathologic Thrombosis
  308. Pathophysiology of Thrombosis
  309. Laboratory Diagnosis of Thrombotic Disorders
  310. Inherited Thrombotic Disorders
  311. Acquired Thrombotic Disorders
  312. The Laboratory’s Role in Diagnosing Thrombophilia
  313. Anticoagulant Therapy
  314. Antiplatelet Drugs
  315. Anticoagulant Drugs
  316. Alternative Anticoagulant Drugs
  317. Thrombolytic Drugs
  318. Part V: Hematology Automation, Flow Cell Cytometry, and Laboratory Procedures
  319. Chapter 20: Hematology Automation and Flow Cell Cytometry
  320. Hematology Automation
  321. Electrical Impedance
  322. Histograms
  323. Radiofrequency
  324. Opacity
  325. Scatterplot
  326. Optical Scatter
  327. VCS Technology
  328. Hydrodynamic Focusing
  329. Flow Cytometry
  330. Optical Platelet Counting and Flow Cytometry
  331. Instruments
  332. Data Reporting
  333. Beckman-Coulter Instrumentation
  334. Sysmex Instrumentation
  335. CellaVision Automated Digital Cell Morphology
  336. Abbott CELL-DYN Instrumentation
  337. Siemens Healthcare Advia Instrumentation
  338. Cerebrospinal Fluid Analysis on the Advia 120/2120
  339. Quality Assurance and Quality Control
  340. Coagulation Automation and Instruments
  341. Coagulation Automation
  342. Coagulation Instruments
  343. Flow Cytometry Instrumentation
  344. Principles of Operation
  345. Fluidics
  346. Optics
  347. Electronics
  348. Analysis
  349. Quality Control
  350. Applications of Flow Cytometry
  351. Chapter 21: Basic Procedures in a Hematology Laboratory
  352. Microhematocrit
  353. Modified Westergren Sedimentation Rate
  354. Manual Reticulocyte Procedure
  355. Peripheral Smear Procedure
  356. Performing a Manual Differential and Assessing Red Blood Cell Morphology
  357. Leukochek White Blood Cell and Platelet Manual Count
  358. Sickle Cell Screening Procedure
  359. Cerebrospinal Fluid and Body Fluid Cell Count and Differential
  360. Body Fluid Analysis on the Sysmex XE-5000
  361. Prothrombin Time and Activated Partial Thromboplastin Time: Automated Procedure
  362. Quantitative D-Dimer—Innovance on Sysmex CA7000
  363. Appendix A: Answers to Review Questions
  364. Appendix B: List of Abbreviations
  365. Glossary
  366. Index

 

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